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In this way, it was made possible for simple segregation of quinazolin-4-ones even with unquantitative cyclization reaction.Compared to traditional heating methods, microwave heating could expand reaction range as well as shorten the reaction time from a few days or hours to a few minutes.
Cu Br reported a kind of tandem Staudinger–Aza-Wittig–Nucleophilic addition reaction to synthesize indolo[1,2-c]quinazolines recently .Store in a tightly sealed container at room temperature and protected from heat or light. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Ketoconazole may result in these side effects: Ketoconazole also blocks the systhesis of cortisone in the adrenal gland, which in some cases may be a harmful side effect, but when used correctly, it’s an effective treatment against Cushing’s syndrome.Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research.This review summarized the representative synthetic methods, either traditional or novel, and categorized them into five main classifications, including Aza-reaction, Microwave-assisted reaction, Metal-catalyzed reaction, Ultrasound-promoted reaction and Phase-transfer catalysis.Besides, three other kinds of reactions were also listed out, which were either designed as supplementary methods in most experiments or used as the main methods in some researches, including Oxidative cyclization, Reagent refluxing and One-pot synthesis.Medicinal chemists synthesized a variety of quinazoline compounds with different biological activities by installing various active groups to the quinazoline moiety using developing synthetic methods.And the potential applications of the quinazoline derivatives in fields of biology, pesticides and medicine have also been explored.The reactions were preceded in toluene as solvent and trifluorotoluene as co-solvent (Scheme ).After the reaction, desired products 15 were separated through solid-extraction on fluorous reversed-phase silica gel, for that the unreacted iminophosphoranes 13 and phosphane oxide 14 would leave the perfluoro tag on silica gel, thus make the products be washed off effectively.They explored the optimal reagent, volume and heating temperature by testing different reagents under different reaction time and temperature.Then under the optimal conditions (2.0 m L glycol and 120°C),several aldehydes were separately reacted with various enaminones and malononitrile to obtain different products (Scheme , the target compounds quinazoline derivatives 28 were obtained by heating an equimolar amount of aldehyde 25, 5,5-dimethyl-1,3-cyclohexanedione (dimedone) 26 and urea/thiourea 27 under microwave irradiation in the absence of solvent and catalyst (Scheme adopted isatoic anhydride and 2-aminobenzimi-dazole as the raw materials, DMAC as solvent in their starting research and got 2-amino-N-(1-H -benzimidazol-2-yl) benzamide under microwave irradiation .