Large Writing Paper

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In the discovery samples (UK Biobank and 23and Me), five autosomal loci were significantly associated with same-sex sexual behavior.

Follow-up of these loci suggested links to biological pathways that involve sex hormone regulation and olfaction.

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In aggregate, all tested genetic variants accounted for 8 to 25% of variation in male and female same-sex sexual behavior, and the genetic influences were positively but imperfectly correlated between the sexes [genetic correlation coefficient (= 0.63; 95% confidence intervals, 0.48 to 0.78].

These aggregate genetic influences partly overlapped with those on a variety of other traits, including externalizing behaviors such as smoking, cannabis use, risk-taking, and the personality trait “openness to experience.” Additional analyses suggested that sexual behavior, attraction, identity, and fantasies are influenced by a similar set of genetic variants ( 0.83); however, the genetic effects that differentiate heterosexual from same-sex sexual behavior are not the same as those that differ among nonheterosexuals with lower versus higher proportions of same-sex partners, which suggests that there is no single continuum from opposite-sex to same-sex preference.

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